The most successful core build consists of Sundered Sky, Black Cleaver, and Guardian Angel, which has a 64.5% win rate. You should start the game with Scorchclaw Pup and Health Potion, then aim to complete Mercury's Treads as your boots. For your first major item, Youmuu's Ghostblade is the most popular choice with a 50.0% win rate.

You should use the Conqueror keystone from the Precision tree, combined with Triumph, Legend: Alacrity, and Coup de Grace. For your secondary tree, take Inspiration with Cosmic Insight and Magical Footwear. This specific rune setup has a 49.5% win rate and is the most picked configuration at 26.6%.

Pantheon Jungle is currently ranked as an S tier pick for Patch 16.2.1. This high ranking is supported by a significant 68.0% overall win rate in Platinum+ games. Despite the high tier, he remains a niche pick with a low 0.6% pick rate.

Pantheon currently holds a 68.0% win rate in the Jungle role across 388 games analyzed in Platinum+ rank. However, the win rate for his specific builds is lower at 45.9%. His high overall win rate contributes to his current S tier status.

While the data is based on Platinum+ games, Pantheon has a low difficulty rating of 4/10 and a solid carry score of 7.5/10. These factors, combined with his S tier ranking and 68.0% win rate, suggest he is very effective if played correctly. His straightforward Q > W > E skill max order makes his mechanics accessible for many players.

With an S tier ranking and a high 7.5/10 carry score, Pantheon is definitely worth considering as a main. He maintains a 68.0% win rate, though his low 0.6% pick rate suggests he is often used as a specialist pick. His build versatility between Fighter and Assassin roles allows for different playstyles.

His 68.0% win rate is exceptionally high, which is likely due to his strong early game pressure and S tier status in the current meta. The low pick rate of 0.6% may also indicate that only experienced Pantheon players are currently utilizing him in the jungle. His ability to carry is reflected in a high 7.5/10 carry score.

The best first item is Youmuu's Ghostblade, which holds a 50.0% win rate and a 16.5% pick rate. It provides the necessary mobility and burst for a champion classified as both a Fighter and Assassin. This item helps him secure early leads during his initial ganks.

You should pick Pantheon when your team needs a strong Fighter or Assassin with a high carry potential of 7.5/10. He is currently an S tier champion, making him a powerful choice despite a low 0.7% ban rate. He is especially effective when you can utilize his 59.1% win rate skill order of Q > W > E.

Pantheon spikes early upon completing Youmuu's Ghostblade and reaching several points in his Q, which is maxed first. With a 68.0% overall win rate, you should play aggressively in the early to mid-game to snowball your lanes. Utilize the Mercury's Treads and Sundered Sky core to maintain your presence in skirmishes.

Pantheon is strongest in the early and mid-game where his high carry score of 7.5/10 and burst damage are most impactful. The build-specific win rate of 45.9% suggests he may struggle if the game goes too late against certain compositions. His skill maxing order of Q > W > E is designed to maximize his mid-game dueling power.

Pantheon received no direct champion changes in Patch 16.2.1. Furthermore, there were no changes to his core items or runes that would affect his performance this patch. He remains in the S tier with his existing kit and stats.

The standard Conqueror and Inspiration setup is currently the most effective, yielding a 49.5% win rate. While matchup data is not available, these runes provide a balanced mix of combat power and utility through Cosmic Insight and Magical Footwear. This setup is the most reliable for his Fighter/Assassin playstyle.