The highest win rate build is Essence Reaver followed by Stormrazor and Infinity Edge, which reaches a 59.5% win rate. Alternatively, the core on-hit build of Blade of The Ruined King, Guinsoo's Rageblade, and Terminus is very effective with a 54.7% win rate.

You should use the Precision tree with Lethal Tempo, Triumph, Legend: Alacrity, and Coup de Grace. For your secondary runes, take Resolve with Conditioning and Overgrowth, a setup that holds a 51.0% win rate.

Vayne Bot is currently ranked in the S Tier for Patch 16.2.1. This placement is supported by a solid 50.5% win rate and a pick rate of 9.2%.

Vayne has a total win rate of 50.5% in the Bot position. Her build-specific win rate is also calculated at 50.5% based on 5420 games analyzed.

While the data is based on Platinum+ rankings, Vayne's S Tier status and 50.5% win rate suggest she is strong. However, her high difficulty rating of 8/10 indicates that she may be harder for low elo players to pilot successfully.

Vayne is definitely worth maining given her S Tier status and a carry score of 5.5/10. With a pick rate of 9.2% and diverse build paths, she offers a lot of potential for players who can master her high-difficulty mechanics.

Vayne's 50.5% win rate is balanced by her high skill ceiling and effective itemization options. She excels with the Stormrazor first item build and the Lethal Tempo rune page, which help her maintain a strong presence in the current meta.

Stormrazor is the best first item for Vayne Bot, boasting a 55.5% win rate. It provides a more successful early game transition compared to other options, especially when following the Q > W > E skill max order.

Vayne is a strong S Tier pick in most situations where you need a high-damage marksman. However, you should be careful picking her into Miss Fortune, as Vayne only has a 47.0% win rate in that specific matchup.

Vayne hits a significant power spike upon completing Stormrazor, which has a 55.5% win rate. You should focus on leveling Q first to increase mobility and play for the mid-to-late game where her S Tier scaling truly shines.

Vayne is most effective in the mid and late game once she has completed her core items like Stormrazor or Blade of The Ruined King. Her 50.5% win rate reflects her ability to scale into a powerful carry despite her 8/10 difficulty.

Vayne received no direct champion changes in Patch 16.2.1. Furthermore, there were no item changes affecting her core build in this patch, leaving her power level consistent.

The Lethal Tempo and Resolve combination is the most popular and successful setup with a 51.0% win rate. While you should generally stick to this for consistency, her secondary Resolve runes like Conditioning and Overgrowth are particularly helpful for surviving difficult lanes.