This is a high-pressure range vs. range lane where Senna starts with an advantage due to her superior reach. As Vayne, you are looking to survive the early poke and find an opening to all-in her, as she is exceptionally squishy once you close the gap. Your mobility is your best tool to dodge her critical skillshots and force a favorable fight.

This is a difficult survival lane for Vayne because Viktor's E outranges her and makes farming dangerous. Viktor's goal is to poke you out and upgrade P, while you just want to reach your core items without falling too far behind in CS.

This is a scaling skill matchup where Vayne must survive early poke to dominate the mid-to-late game duels. Viktor has superior waveclear and range, but Vayne's mobility can make his primary damage tools unreliable. You win by dodging his telegraphed lasers and forcing long trades where your sustained damage outvalues his burst.