Heimerdinger dominates this lane early through superior wave pressure and zone control. Vayne is a short-ranged marksman who struggles to clear Q turrets without taking massive poke. If you keep your turrets healthy, she can never engage on you without dying.

This is a lane of extreme pressure vs. scaling. You win by shoving Q under her tower constantly because she has zero waveclear. If you let her freeze or get a long lane to chase you down with P, she will shred you with true damage.